According to tradition, it was built by Saint Petronius, who was bishop of the city during the 5th century, over a temple of the goddess Isis. The church of St. John the Baptist (or of the Holy Crucifix) dates from the 8th century, while that of the Holy Sepulchre from the 5th (renovated in the 12th century), as well as that of San Vitale ed Agricola (renovated in the 8th and 11th centuries). A 13th century portico known as "Pilatus' court" connects the other buildings to the church of the Holy Trinity (13th century).
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