Lysko was born on 14 August 1914 in Horodok, Lviv Oblast. He studied theology and graduated from the Lviv Theological Academy. On August 28, 1941 he was ordained a priest by Metropolitan Andrey Sheptytsky. He was Pastor of the Archeparchy of Lviv for Ukrainians. Lysko was also active in working with youth.
On 9 September 1949, he was arrested by the NKVD. He was put into prison in Lviv. The people of the city reported hearing him loudly sing Psalms after he was tortured. His torturers reportedly thought he had gone insane. He died from starvation after being immured in the prison walls. The official date of his death was 14 October 1949.
- Biographies of twenty five Greek-Catholic Servants of God at the website of the Vatican
- Beatification of the Servants of God on June 27, 2001 at the website of the Ukrainian Greek Catholic Church
- Francisco Radecki. Tumultuous Times: The Twenty General Councils of the Catholic Church and Vatican II and Its Aftermath. St. Joseph's Media, 2004.
- Blessed Roman Lysko Patron Saints Index.ru:Лыско, Роман