Fandom

Religion Wiki

Mescaline

34,278pages on
this wiki
Add New Page
Talk0 Share

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.

Mescaline or 3,4,5-trimethoxyphenethylamine is a naturally occurring psychedelic alkaloid of the phenethylamine class. It is mainly used as an entheogen, and a tool to supplement various practices for transcendence, including in meditation, psychonautics, art projects, and psychedelic psychotherapy.

It occurs naturally in the peyote cactus (Lophophora williamsii),[1] the San Pedro cactus (Echinopsis pachanoi) and the Peruvian Torch cactus (Echinopsis peruviana), and in a number of other members of the Cactaceae. It is also found in small amounts in certain members of the Fabaceae (bean family), including Acacia berlandieri.[2] Mescaline was first isolated and identified in 1897 by the German Arthur Heffter and first synthesized in 1919 by Ernst Späth.

History and usage

Peyote has been used for over 3000 years by Native Americans in Mexico.[1] Europeans noted use of peyote in Native American religious ceremonies upon early contact, notably by the Huichols in Mexico. Other cacti such as the San Pedro have been used in different regions, from Peru to Ecuador.

Aldous Huxley experimented with the use of mescaline. So did Aleister Crowley as reported in his diary, as well as the famous sex psychologist Havelock Ellis. By coincidence or experimentation, mescaline may have played a part in the development of the Cubist school of abstract art. When George Braque and Pablo Picasso published the "Cubist Manifesto" they described design paradigms which were similar to visual experiences induced by mescaline and other rare drugs known to the South American Islanders.[3]

Hunter S. Thompson famously recounted his use of mescaline in a number of his works including his most famous; Fear and Loathing in Las Vegas.

In traditional peyote preparations the top of the cactus is cut at ground level, leaving the large tap roots to grow new 'Heads'. These 'Heads' are then dried to make disk-shaped buttons. Buttons are chewed to produce the effects or soaked in water for an intoxicating drink. However, the taste of the cactus is bitter, so users will often grind it into a powder and pour it in capsules to avoid having to taste it. The usual human dosage is 200–400 milligrams of mescaline sulfate or 178–356 milligrams of mescaline hydrochloride[4]. The average 3 inch button contains about 25 mg mescaline.[5]

Pharmacokinetics

Although the ED50 is variable with dosage and individual, the LD50 has been measured in various animals and is reported as follows:

  • 212 mg/kg i.p. (mice)
  • 132 mg/kg i.p. (rats)
  • 328 mg/kg i.p. (guinea pigs)

About half the initial dosage is excreted after six hours, but some studies suggest that it is not metabolized at all before excretion.

Tolerance builds with repeated usage.

Mescaline appears to not be subject to metabolism by CYP2D6[6] and between 20 and 50% of mescaline is excreted in the urine unchanged, and the rest being excreted as the carboxylic acid form of mescaline, a likely result of MAO degradation.[7]

Behavioral and non-behavioral effects

Hallucinations produced by mescaline are somewhat different from those of LSD. Hallucinations are consistent with actual experience, but are typically intensifications of the stimulus properties of objects and sounds. Prominence of color is distinctive, appearing brilliant and intense. Placing a strobing light in front of closed eyelids can produce brilliant visual effects at the peak of the experience. Recurring visual patterns observed during the mescaline experience include stripes, checkerboards, angular spikes, multicolored dots, and very simple fractals which turn very complex. Aldous Huxley described these self transforming amorphous shapes as like animated stained glass illuminated from light coming through the eyelids. Like LSD, mescaline induces distortions of form and kaleidoscopic experiences but which manifest more clearly with eyes closed and under low lighting conditions; however, all of these visual descriptions are purely subjective. And like with LSD, synesthesia can occur especially with the help of music.[8] An unusual but unique characteristic of mescaline use is the "geometricization" of three-dimensional objects. The object can appear flattened and distorted, similar to the presentation of a Cubist painting.[9]

Mescaline elicits a pattern of sympathetic arousal, with the peripheral nervous system being a major target for this drug.[8] Effects last for up to 12 hours.[8]

Mode of action

Mescaline acts similarly to other psychedelic agents.[10] Mescaline binds to, and activates the serotonin 5-HT2A receptor with a high nanomolar affinity.[11] How activating the 5-HT2A receptor leads to hallucinations is still unknown, but it likely somehow involves exciting cortical neurons.[12]

Legality

In the US mescaline was made illegal in 1970 by the Comprehensive Drug Abuse Prevention and Control Act.[13] It was prohibited internationally by the 1971 Convention on Psychotropic Substances[14] and is categorized as a Schedule I hallucinogen by the CSA. Mescaline is only legal for certain natives (such as those involved in the Native American Church). In 1990, the Supreme Court ruled that the state of Oregon could bar the use of mescaline in Native American religious ceremonies. The Religious Freedom Restoration Act in 1993 allowed the use of peyote in religious ceremony but in 1997, the Supreme Court ruled that RFRA was unconstitutional when applied against states. However, a subsequent ruling in 2006 held that RFRA was constitutional when applied against the federal government.[15] Thus, the current state of the law is that, while the federal government may not restrict use of peyote in ceremony, individual states do have a right to restrict it.[16] Penalties for manufacture or sale can be as high as five years in prison and a fine of $15,000, with a penalty of up to one year and fine of $5000 for possession.

In the UK, mescaline is a Class A drug (in powder form, although dried cactus can be bought and sold legally, unlike raw "magic" mushrooms, which are now illegal),[17] and so carries the following penalties. For possession: up to seven years in prison or an unlimited fine or both. For dealing: up to life in prison or an unlimited fine or both.

In Canada, mescaline in raw form is considered an illegal drug. However, anyone may grow and use peyote, or Lophophora williamsii, without restriction, as it is specifically exempt from legislation.[1]

Analogs

Mescaline has a number of analogs, featuring the methoxy groups altered to include thio groups or to be extended. Examples include, but are not limited to, isomescaline, thiomescaline, escaline, thioescaline, proscaline, isoproscaline, buscaline, thiobuscaline, thioisomescaline, phenescaline, symbescaline, asymbescaline, thioasymbescaline, allylescaline, methallylescaline, metaescaline and thiometaescaline. It has an active amphetamine homolog, 3,4,5-trimethoxyamphetamine.

References

Notes

  1. 1.0 1.1 1.2 Drug Identification Bible. Grand Junction, CO: Amera-Chem, Inc.. 2007. ISBN 0-9635626-9-X. 
  2. Chemistry of Acacia's from South Texas
  3. AJ Giannini. Drugs of Abuse—Second Edition. Los Angeles, Practice Management Information Corp., 1997.
  4. http://www.erowid.org/library/books_online/pihkal/pihkal096.shtml
  5. AJ Giannini, AE Slaby, MC Giannini. Handbook of Overdose and Detoxification Emergencies.New Hyde Park, NY. Medical Examination Publishing/Excerpta Medica Company,1982.
  6. Wu D, Otton SV, Inaba T, Kalow W, Sellers EM (June 1997). "Interactions of amphetamine analogs with human liver CYP2D6". Biochem. Pharmacol. 53 (11): 1605–12. http://linkinghub.elsevier.com/retrieve/pii/S0006-2952(97)00014-2. 
  7. Cochin J, Woods LA, Seevers MH (February 1951). "The absorption, distribution and urinary excretion of mescaline in the dog". J. Pharmacol. Exp. Ther. 101 (2): 205–9. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=14814616. 
  8. 8.0 8.1 8.2 Diaz, Jaime. How Drugs Influence Behavior. Englewood Cliffs: Prentice Hall, 1996
  9. AJ Giannini, AE Slaby. Drugs of Abuse. Oradell, NJ. Medical Economics Books,1989, pp.207-239.
  10. Nichols DE (February 2004). "Hallucinogens". Pharmacol. Ther. 101 (2): 131–81. 
  11. Monte AP, Waldman SR, Marona-Lewicka D, et al. (September 1997). "Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives". J. Med. Chem. 40 (19): 2997–3008. 
  12. Béïque JC, Imad M, Mladenovic L, Gingrich JA, Andrade R (June 2007). "Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex". Proc. Natl. Acad. Sci. U.S.A. 104 (23): 9870–5. 
  13. United States Department of Justice. "Drug Scheduling". http://www.usdoj.gov/dea/pubs/scheduling.html. Retrieved 2007-11-02. 
  14. "List of psychotropic substances under international control". International Narcotics Control Board. http://www.incb.org/pdf/e/list/green.pdf. Retrieved 2008-01-27. 
  15. [http://caselaw.lp.findlaw.com/cgi-bin/getcase.pl?court=US&navby=case&vol=000&invol=04-1084 GONZALES, ATTORNEY GENERAL, et al. v. O CENTRO ESPIRITA BENEFICENTE UNIAO DO VEGETAL et al.]
  16. "Uses Drugs of Abuse—Origins and Effects - Hallucinogens". http://www.libraryindex.com/pages/2339/Drugs-Abuse-Origins-Uses-Effects-HALLUCINOGENS.html. 
  17. "2007 U.K. Trichocereus Cacti Legal Case Regina v. Saul Sette". http://www.erowid.org/plants/cacti/cacti_law2.shtml. 

External links

Smallwikipedialogo
This page uses content from the English Wikipedia. The original article was at Mescaline. The list of authors can be seen in the page history.

Also on Fandom

Random Wiki