The Great Prokeimenon is a longer form of a prokeimenon sung at Vespers (for example, on Sunday evenings in the Great Fast, and at the All-Night Vigil on Saturday Evening). It consists of additional phrases, the last of which is a repeat of the first. It is not necessarily connected to scripture readings.

The verses which follow the readings at the Liturgy of the Presanctified Gifts, with the refrain "Let my prayer be directed as incense before Thee," may also be considered a Great Prokeimenon.

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