Francesco Maria Macchiavelli (1608 in Firenze, Italy – 22 November 1653 in Ferrara) was a cardinal of the Catholic Church. He was bishop of Ferrara from 1638 to 1653.

He was made a cardinal on the 16 December 1641 by Pope Urban VIII, was the nephew of cardinal Lorenzo Magalotti and the cousin of cardinals Francesco Barberini the elder and Antonio Barberini the younger.

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