Edward and Anna Gonzaga were parents of three children:
- Louisa Mary (23 July 1647 – 11 March 1679). Married Charles Theodore, Prince of Salm.
- Anne Henriette (23 July 1648 – 23 February 1723). Married Henry III, Prince of Condé.
- Benedicta-Henrietta (14 March 1652 – 12 August 1730). Married John Frederick, Duke of Brunswick-Lüneburg.
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