- Not to be confused with Cardinal Antonio Barberini (1607-1671)
Born in Florence, he was a member of the Order of Capuchins. He was bishop of Senigallia (1625-1628), Grand Inquisitor of the Roman Inquisition (1629-1633), Librarian of the Holy Roman Church (1633-1646) and Grand penitentiary (1633-1646). He participated in the papal conclave, 1644. Died at Rome, at the age of 77.