The events of David Macaulay's Motel of the Mysteries take place in 4022.
The song Wykydtron by Canadian metal band 3 Inches of Blood is set in a dystopian year 4055.
The Blasterman universe mainly takes place in the early 4060's.
The events of the Doctor Who episode 42 take place in the 42nd century.
The events of the Doctor Who episode Planet of the Ood take place in the 42nd century, in the year 4126. The Ood cease to be slaves to humans at this point in time.
In the film A. I., which begins in the mid 22nd century, a sequence said to take place 2000 years later, features the extinction of mankind after the ocean freezes over, but the descendants of mankind's early intelligent robots, the Mechas, return to Earth and are seen excavating parts of frozen-over NYC to discover their origins and discover an ancient android, a boy named David.
Susan from the television programme Doctor Who is born in the 49th century.
The novel series Fifth Millennium by Stirling, Wehrstein and Meier is set in this time, chronicling the lives and travels of several connected characters in a 'low magic' fantasy world that emerged after a nuclear war destroyed almost all former civilization on Earth.
The Japanese anime Battle Athletes takes place in 4999 at an athletic training school in Antarctica, which is located on the equator after a great catastrophe in 2015.
In several stories written by H. P. Lovecraft, the beginning of "the cruel Tsan-Chan Empire" will take place in the year 5000.
The Ratchet and Clank series on PlayStation is theorized to take place in the 4790s, due to one character in the 2nd game stating, "Log-entry 4792...". Since all the games take place a year after each preceding one, the timeline goes from 4791 to 4798.