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Five kinds of loss:
1. Loss of relatives
2. Loss of wealth
3. Loss through disease
4. Loss in terms of virtue
5. Loss in terms of views
(from Anguttara Nikaya 5.130)
(It's not by reason of loss of relatives, loss of wealth, or loss through disease that beings are reborn to bad destinations. It’s by reason of loss in terms of virtue and loss in terms of views that beings are reborn to bad destinations.)